Carriage of HBs Antigen and Hepatitis C Virus in Human Immunodeficiency Virus (HIV) Positive People at the Grand-Yoff General Hospital in Dakar, Senegal
Abdou Diop *
Immunology Department, FMPO, Cheikh Anta Diop University of Dakar, Senegal and Medical Biology Laboratory, Idrissa Pouye General Hospital, Grand-Yoff, Dakar, Senegal.
Antoine Sylva
Care Center for People Living with HIV, Idrissa Pouye General Hospital, Grand-Yoff, Dakar, Senegal.
Niokhor Ndane Diouf
Medical Biology Laboratory, Idrissa Pouye General Hospital, Grand-Yoff, Dakar, Senegal.
Ousseynou Boye
Medical Biology Laboratory, Idrissa Pouye General Hospital, Grand-Yoff, Dakar, Senegal.
Khadidiatou Sarr Fall
Medical Biology Laboratory, Idrissa Pouye General Hospital, Grand-Yoff, Dakar, Senegal.
Moustapha Mbow
Immunology Department, FMPO, Cheikh Anta Diop University of Dakar, Senegal.
Babacar Mbengue
Immunology Department, FMPO, Cheikh Anta Diop University of Dakar, Senegal.
Alioune Dièye
Immunology Department, FMPO, Cheikh Anta Diop University of Dakar, Senegal.
Maguette Sylla Niang
Immunology Department, FMPO, Cheikh Anta Diop University of Dakar, Senegal and Medical Biology Laboratory, Idrissa Pouye General Hospital, Grand-Yoff, Dakar, Senegal.
*Author to whom correspondence should be addressed.
Abstract
Objective: To investigate the carriage of HBs antigen (Ag) and hepatitis C virus in people with human immunodeficiency virus (HIV) at Grand-Yoff General Hospital.
Materials and Methods: Sera from patients living with HIV and monitored at Grand-Yoff General Hospital have benefited from research for HBs Ag, HBe Ag, anti-H[8] Be antibodies and on these co-infected patients, a test for hepatitis C virus was also carried out.
Results: This study included 147 HIV-infected patients and including 95 women (64.63%) and 52 men (35, 37%) with a median age of 46 years (16-78 years). The gender ratio is M/W was 0.54 and the age group most represented at inclusion was 30-39 years old with 31.97% of patients. 12, 25% of patients were co-infected HIV and hepatitis B including 11 women (61.11%) and 7 men (38.89%). The median age was 39.5 years (33-60 years), women were the affected by co-infection and 44.44% of them were married. Chronic hepatitis B and hepatitis C markers were tested for in HIV/HBV coinfected patients using a microparticulate chemiluminescence immunoassay technic. Investigation of hepatitis B chronicity markers indicated that all patient, except one, underwent anti-HBe seroconversion (94.4%) and no case of co-infection with HCV had been noted. During follow-up, all patients were under antiretroviral therapy with mainly tenofovir (TDF) which was the most used molecule with 83.33%, followed by lamivudine (3TC) 16.67%.
Conclusion: HIV infection is a major public health problem when it is associated with hepatitis B and C virus.
Keywords: Co-infection, hepatitis, HIV, HCV