Biological Properties and Phytochemical Analysis of Fractions and Total Extracts of Cylicodiscus gabunensis Harms and Morinda lucida Benth
Cédric Sima Obiang
*
Laboratoire de Recherche en Biochimie (LAREBIO), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon and Laboratoire de Substances Naturelles et de Synthèses Organométalliques (LASNSOM), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
Rick Léonid Ngoua Meye Misso
Laboratoire de Recherche en Biochimie (LAREBIO), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon and Laboratoire de Substances Naturelles et de Synthèses Organométalliques (LASNSOM), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
Elvis Otogo N’Nang
Laboratoire de Substances Naturelles et de Synthèses Organométalliques (LASNSOM), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
Joseph Privat Ondo
Laboratoire de Recherche en Biochimie (LAREBIO), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon and Laboratoire de Substances Naturelles et de Synthèses Organométalliques (LASNSOM), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
Guy Roger Ndong Atome
Laboratoire de Recherche en Biochimie (LAREBIO), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon and Laboratoire de Substances Naturelles et de Synthèses Organométalliques (LASNSOM), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
Louis Clément Obame Engonga
Laboratoire de Recherche en Biochimie (LAREBIO), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon and Laboratoire de Substances Naturelles et de Synthèses Organométalliques (LASNSOM), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
Edouard Nsi Emvo
Laboratoire de Recherche en Biochimie (LAREBIO), Université des Sciences et Techniques de Masuku, BP 943, Franceville, Gabon.
*Author to whom correspondence should be addressed.
Abstract
Two plants used in traditional medicine from Gabon were studied. The aim of this study was to study the biological properties and phytochemical analysis of Cylicodiscus gabunensis Harms and Morinda lucida Benth. These extracts were subjected to antimicrobial (diffusion, dilution), antioxidant (DPPH, ABTS) and inhibition of protein denaturation. The water-ethanol, water-acetone extracts and the partitioned extracts (F1 and F2) of Cylicodiscus gabunensis showed the greatest antibacterial activity on the majority of microbial strains and a good inhibition of denaturation with IC50 of 58.75 ± 2.10; 19.16 ± 2.00; 69.50 ± 2.00 and 17.49 ± 1.20 μg / mL respectively, compared to standards. Similarly, these extracts of Cylicodiscus gabunensis have anti-free radical capacities close to standards including vitamin C and butylated hydroxyanisole. The phytochemicals present in the extracts of Cylicodiscus gabunensis and Morinda lucida may be responsible for the biological activities studied.
Keywords: Antibacterial, denaturation inhibition, anti-free radical, DPPH, ABTS