Association of Helicobacter pylori Infection with Respiratory Diseases in Cameroon Patients, Using GastroPanel® Serological Biomarkers (Pepsinogen I; Pepsinogen II; Gastrin-17; Helicobacter pylori IgG)
Alonge Ivo Ebule *
Faculty of Science, University of Buea, Cameroon and School of Assistant laboratory Technologies, Limbe, Cameroon.
Valentine Ngum Ndze
Faculty of Health Sciences, University of Buea, Cameroon.
Ngouana Kammalac Thierry
Antimicrobial and Biocontrol Agent Unit, University of Yaounde, Cameroon.
Guenou Etienne
Faculty of Science, University of Buea, Cameroon and M. A .SANTE (Meilleur Acces aux Soins de Santé), Younde, Cameroon.
Ndja Heu Ines Vanella
School of Laboratory TechniciansYaounde, Cameroon.
Bouorewo Tchinda Naquine Nibeline
School of Laboratory TechniciansYaounde, Cameroon.
Noah Noah Dominique
Faculty of Medicine and Pharmaceuticals Sciences, University of Douala, Cameroon.
Minna Maki
Department of Clinical Research, Biohit Oyj, Helsinki, Finland.
Kari Syrjanen
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Helicobacter pylori (H. pylori) is a microaerophilic gram-negative bacterium that colonizes the gastric mucosa and provokes inflammation and immune responses throughout life with liberation of diversecytotoxique substances dependent on host. Infection to H. pylori has been associated to a number of respiratory complications, including chronic obstructive pulmonary dieases, bronchectasis, asthma, tuberculosis and lung cancer. Epidemiological data on the association of H. pylori infection respiratory diseases are rare in Cameroon. We sought to evaluate the prevalence H. pylori infection among patient with respiratory diseases.
Methodology: Blood samples were aseptically collected for the measurements Helicobacter pylori IgG antibodies, pepsinogene I et II levels, gastrine-17. The blood samples required for the study were collected prospectively. Ethical clairance was obtained from the Centre Regional Ethics Committee for Human Sciences. An authorization of research was obtained from the authorities of Jamot Hospital of Yaounde. All participants signed an informed consent form.
Results: The GastroPanel® results showed that the prevalence of H. pylori infection was 42(46.67%). We observed an H. pylori seroprevalence of 75%, 41.9%, 50.0% and 33,33% amongst sujects with bronchitis, Tuberculosis, Asthma and pneumonia respectively.
Keywords: Helicobacter pylori infection, respiratory diseases, gastropanel, serological Biomarkers