Helicobacter pylori Infection and Association with Anaemia in Cameroon Patients, Using GastroPanel® Serological Biomarkers (Pepsinogen I; Pepsinogen II; Gastrin-17; Helicobacter pylori IgG)
Alonge Ivo Ebule *
Faculty of Science, University of Buea, Cameroon and School of Assistant laboratory Technologies, Limbe, Cameroon.
Valentine Ngum Ndze
Faculty of Health Sciences, University of Buea, Cameroon.
Ngouana Kammalac Thierry
Antimicrobial and Biocontrol Agent unit, University of Yaounde, Cameroon.
Nken Ester
Protestant University of Central Africa, Cameroon.
Noah Noah Dominique
Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon.
Minna Maki
Department of Clinical Research, Biohit Oyj, Helsinki, Finland.
Kari Syrjanen
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Helicobacter pylori (H. pylori) together with chronic atrophic gastritis have also been associated to extragastric manifestations including neurological, dermatological, ocular, cardiovascular, metabolic, allergic diseases and hematologic disorders. Several studies have associatedH. pylori with anaemia, iron deficiency and iron deficiency anemia. Little or no data on the association of H. pylori infection andanaemia exist in Cameroon. We therefore evaluated the prevalence H. pylori infection among patients with anaemia.
Methodology: Blood samples were aseptically collected for the measurements Helicobacter pylori IgG antibodies, pepsinogene I et II levels, gastrine-17 in a total of 150 patients during the period February to July 2020. The blood samples required for the study were collected prospectively. Ethical clairance was obtained from the Centre Regional Ethics Committee for Human Sciences. An authorization of research was obtained from the authorities of General Hospital of Yaounde. All participants signed an informed consent form.
Results: The GastroPanel® results showed that the prevalence of H. pyloriinfection was 90(60.00%).We observeda strong association of H. pylori with anaemia (OR 2.19, 95% CI 1.08–4.46; p=0,02).
Conclusion: The prevalence of H. pylori infection is high in patients with anaemia and thus requires continuous monitoring of these patients.
Keywords: Helicobacter pylori, anaemia, gastropanel®, serological biomarkers